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Chemistry Basics: Advanced Crossword Puzzle Mark as Favorite (15 Favorites)

ACTIVITY in Density, Physical Properties, Periodic Table, Review, Mixtures. Last updated January 29, 2024.


In this activity, students will complete a crossword puzzle by solving each clue that is related to a fundamental chemistry topic.

Grade Level

High and Middle School


By the end of this activity, students should be able to

  • Demonstrate a good understanding of fundamental chemistry topics.

Chemistry Topics

This activity supports students’ understanding of

  • Matter
  • Density
  • Mixtures
  • Physical Properties
  • Separating Mixtures
  • History
  • Atomic Structure
  • Atomic Models
  • Subatomic Particles
  • Atomic Mass
  • Electrons


Teacher Preparation: minimal

Lesson: 15 - 20 minutes


  • Crossword puzzle & clues


  • No specific safety precautions need to be observed for this activity.

Teacher Notes

  • This crossword puzzle could be a used at the beginning of the school year with high school students, to gauge their prior knowledge. Alternately it could be used at the end of first or second units in a high school chemistry class.
  • This crossword puzzle could also be used at the middle school level, during a physical science class, however several clues will be challenging.
  • An answer key document has been provided for teacher reference.

Chemistry Crossword

Chemistry Basics: Advanced Crossword Clues


1. Carbon monoxide (or perhaps the state of Colorado)

6. Currently, there are 118 ______ on the periodic table

7. 6.02 x 1023 atoms

8. What an element's atomic number represents

11. For water, it is 1 g/ml (or equivalently 1 g/cm3)

12. Number of valence electrons for Lithium, or any other alkali metal in group 1

16. Product of cellular respiration

19. Color, melting point, smell, or density

20. Charged atoms

22. The periodic table has 18 groups and 7 _____

24. Dihydrogen Monoxide

25. Famous atomic model named after a Danish scientist

26. Food for plants


1. The formation of bubbles, or a release of gas, is a potential indication that this has occurred

2. Something that has mass and takes up space

3. Combination of two or more substances

4. Method for separating rocks from sand

5. Method for separating salt from water

9. pH, flammability, reactivity, or combustion

10. Law stating that matter is neither created nor destroyed

13. Mass divided by volume

14. Principle ingredient in old thermometers

15. Process for purifying a liquid (such as water)

17. ______ _____ is equal to the weighted average of an element's isotopes

18. The study of how matter is made and how it changes

21. 78% of the earth's atmosphere

23. Potent greenhouse gas