In this activity, students will use the periodic table, combined with math and logic to solve several chemistry themed pyramid puzzles. In a traditional pyramid puzzle, there is a relationship between the numbers, which is used to determine the missing numbers. In all of these chemistry pyramids, each element symbol is determined by the sum of the two atomic numbers of the elements directly below it. Students are challenged with determining the missing element symbols in each puzzle, but first must use a periodic table to find the atomic number for each element symbol appearing in the puzzle. This activity is a fun challenge for students and provides the opportunity to strengthen logic and reasoning skills.